This site is intended for patients in Great Britain (England, Scotland and Wales) who have been prescribed PIQRAY®▼ (alpelisib) + fulvestrant.

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Why have I been prescribed Piqray?

You have been prescribed Piqray® (alpelisib) because your doctor believes you are of a specific subset of men or women who could benefit from this treatment.

PIQRAY is a treatment given to postmenopausal women, or men, who:1

  • have tested positive for a mutation, or abnormality, in a gene called PIK3CA – mutations in PIK3CA have been linked to breast cancer growth1–6
  • have hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) advanced breast cancer
  • have had a progression of their aBC following hormone-based therapy

Piqray is given in combination with another medicine called fulvestrant (see How do I take Piqray? for more information).1

Piqray is the brand name used for alpelisib.

Choose a topic below to learn more about Piqray

How Piqray works, image of doctor and patient

How does it work?

Find out more about how Piqray works in the body of people with aBC

Why have I been prescribed, doctor with clipboard

How do I take Piqray?

Find out more about how to take your medication correctly

Side effects, image showing a nurse and a woman holding her head

What side effects could I experience?

Learn about the possible side effects of taking Piqray and what to do

Resource banner image, woman on sofa

Browse through a range of helpful materials ranging from information about your diagnosis, Piqray treatment and living well with aBC

Browse downloadable resources >

Abbreviations

aBC, advanced breast cancer; HER2-, human epidermal growth factor receptor 2-negative; HR+, hormone receptor-positive; PIK3CA, phosphatidylinositol-4,5-biphosphate 3-kinase catalytic subunit alpha.
 

References

  1. PIQRAY® (alpelisib) Patient Information Leaflet. Available at: https://www.medicines.org.uk/emc/product/11684/pil. [Accessed November 2021].
  2. Croessmann S, et al. Clin Cancer Res. 2018;24(6):1426–1435.
  3. Sobhani N, et al. J Cell Biochem. 2018;119(6):4287–4292.
  4. Li SY, et al. Breast Cancer Res Treat. 2006;96(1):91–95.
  5. Lai YL, et al. Ann Surg Oncol. 2008;15(4):1064–1069.
  6. Mosele F, et al. Abstract 4895 presented at American Association for Cancer Research (AACR) Annual Meeting; 29 March–3 April 2019; Atlanta, GA, USA.

▼This medicine is subject to additional monitoring. This will allow quick identification of new safety information. You can help by reporting any side effects you may get. See www.mhra.gov.uk/yellowcard for how to report side effects.

UK | January 2022 | 147265